In virtualized environments In-Guest iSCSI support is still a hard requirements if one of the following scenarios is pursued:
- Microsoft Failover Clustering (MSFC) in a VMware vSphere environment
- A supported MS Exchange 2013 Environment in a VMware vSphere environment
Microsoft explicitely does not support NFS in both scenarios.
Nutanix, ECP [HCI]/5.10, Starter
Hypervisor Interconnect, Virtualization, Workload Support