StorPool supports all 64-bit Linux distributions. The following platform versions have been tested thoroughly and are thus supported by default:
- CentOS 7, 8
- Debian Linux 9
- Ubuntu Linux 16.04 LTS, 18.04 LTS
Other Linux distributions (eg. RHEL, OEL, SuSE) can be supported.

The Windows Server OS is supported through iSCSI.

StorPool HCI nodes as well as StorPool storage-only nodes run one of the supported Linux distributions.