Cisco HyperFlex (HX) compute+storage nodes are based on Cisco UCS C220 M5 and Cisco UCS C240 M5 rack server hardware. M4 server hardware reached End-of-Life (EOL) status on February 14th 2019. This means that end users cannot acquire M4 hardware any longer.

Cisco HyperFlex (HX) compute-only nodes are based on Cisco UCS B200 M4/M5, B260 M4/M5, B420 M4/M5 and B460 M4/M5 blade server hardware. The Cisco C220 M4/M5, C240 M4/M5 and C460 M4/M5 rack servers can optionally be used as compute-only nodes.

Cisco HyperFlex 4.0 introduces support for C480 ML compute-only nodes that serve in Deep Learning / Machine Learning environments.