Product : HPE, SimpliVity [HCI]/3.7.9, 380
Feature : Hypervisor Interconnect, Virtualization, Workload Support
Content Owner:  Herman Rutten
Summary
NFS
SMB
Details
NFS is used as the storage protocol in vSphere environments.
SMB3 is used as the storage protocol in Hyper-V environments.

In virtualized environments In-Guest iSCSI support is still a hard requirements if one of the following scenarios is pursued:
- Microsoft Failover Clustering (MSFC) in a VMware vSphere environment
- A supported MS Exchange 2013 Environment in a VMware vSphere environment

Microsoft explicitely does not support NFS in both scenarios.