NFS is used as the storage protocol in vSphere environments.
SMB3 is used as the storage protocol in Hyper-V environments.
In virtualized environments In-Guest iSCSI support is still a hard requirements if one of the following scenarios is pursued:
- Microsoft Failover Clustering (MSFC) in a VMware vSphere environment
- A supported MS Exchange 2013 Environment in a VMware vSphere environment
Microsoft explicitely does not support NFS in both scenarios.
HPE, SimpliVity [HCI]/4.0.0, 380
Hypervisor Interconnect, Virtualization, Workload Support