Although Storage Spaces Direct (S2D) supports Scale-out File Server, it is primarily meant to be used in Hyper-V and MS SQL use cases. In cases where standard file services (eg. home folders or shared departmental folders) are needed, Microsoft recommends to virtualize a Windows file server in Hyper-V.
Storing generic data on Scale-Out File Server is possible but not recommended by Microsoft. It is not recommended because Scale-out file Server does not provide some of the common file services features such as quotas and DFS.
For these use cases Microsoft recommends to rely on Windows guest VMs (SMB) and/or Linux guest VMs (NFS) to provide file services on top of S2D. These file services can be made highly available by using clustering techniques.
Microsoft, S2D [SDS]/2.0, Datacenter
Fileserver Compatibility, File Services, Data Services