Product : Microsoft, S2D [SDS]/2.0, Datacenter
Feature : Mixing Allowed, Server/Node, Server Support
Content Owner:  Herman Rutten
Summary
Yes
Details
Storage Spaces Direct (S2D) accepts that different server hardware can be added to the cluster.

If the capacity of the storage devices are not the same, the capacity used will be the same as the smallest available.

When deploying S2D in a single-layer model, be careful about live migrating VMs between nodes with dissimilar CPUs (eg. mixing AMD servers with Intel servers within the same cluster).