Storage Spaces Direct (S2D) is supported for use in MS SQL Server solutions.
When deploying S2D with Scale out File Server on top, file services are supported. This mean you can store data such as Hyper-V VM, RDS Profile (UPD), or more generic data such as Word and PowerPoint, even though this is not recommended by Microsoft. SMB shares are supported but no NFS shares or iSCSI targets.
Microsoft, S2D [SDS]/2019, Datacenter
Bare Metal Compatibility, Bare Metal, Workload Support