Microsoft Hyper-V 2012R2 (Dual Layer)
Microsoft Hyper-V 2016/2019
Storage Spaces Direct (S2D) is an integral part of the Microsoft Windows Server 2019 platform. As such it cannot be used with any other hypervisor platform than Hyper-V.
S2D supports a single hypervisor in contrast to other SDS/HCI products that support multiple hypervisors.
Both S2D deployment models (single-layer, dual layer) can be used in conjunction with Hyper-V. When setup in a dual-layer configuration, the storage nodes with S2D act as scale-out file servers that present storage to the Hyper-V compute nodes.
Microsoft, S2D [SDS]/2019, Datacenter
Hypervisor Compatibility, Virtualization, Workload Support