Microsoft Windows Server 2008R2/2012R2/2016
Red Hat Enterprise Linux (RHEL) 6.7/6.8/7.2
Oracle Linux 6.7/7.2
AIX 7.1/7.2 on POWER
Oracle Solaris 11.3 on SPARC
ESXi 5.5/6 with VMFS (very specific use-cases)
Nutanix Volumes, previously Acropolis Block Services (ABS), provides highly available block storage as iSCSI LUNs to clients. Clients can be non-Nutanix servers external to the cluster or guest VMs internal or external to the cluster, with the cluster block storage configured as one or more volume groups. This block storage acts as the iSCSI target for client Windows or Linux operating systems running on a bare metal server or as guest VMs using iSCSI initiators from within the client operating systems.
AOS 5.5 introduced support for Windows Server 2016.
IBM AIX: PowerHA cluster configurations are not supported as AIX requires a shared drive for cluster configuration information and that drive cannot be connected over iSCSI.
Nutanix Volumes supports exposing LUNs to ESXi clusters in very specific use cases.
Nutanix, ECP [HCI]/5.11, Ultimate
Bare Metal Compatibility, Bare Metal, Workload Support