Software: No (Bitlocker); No (VMware Virtual Machine Encryption)
Hardware: Because data encryption is performed at the end of the write path, storage efficiency mechanisms are not impaired.
Software: Microsoft BitLocker can be used to provide whole-disk encryption on a deduplicated disk since BitLocker sits at the end of the write path. VMware Virtual Machine Encryption encrypts tge data on the host before it is written to storage, thus negatively impacting backend storage features such as deduplication and compression. However, Microsoft post-process deduplication is executed at the filesystem layer.
StarWind, Virtual SAN [SDS]/13279, x86
Data Encryption Efficiency Impact, Security, Data Services