System Center 2016 Datacenter: $3,607 or Standard $1,323 per managed endpoint (up to 16 physical cores)
The System Center 2016 Datacenter license model is like Windows Server 2016. A single licence covers 16 physical cores on a server. If the server has more CPU, you need to buy extra licences packs. The System Center 2016 standard is based on managed endpoint.
For virtualize environment, you just have to buy licenses for the Hyper-V hosts.