RHV supports the most common server and technical workstation OSs as well as PPC guests, current support includes:
For X86_64 hosts:
- Microsoft Windows 10, Tier 1, 32\64 bit
- Microsoft Windows 7, Tier 1, 32\64 bit
- Microsoft Windows 8, Tier 1, 32\64 bit
- Microsoft Windows 8.1, Tier 1, 32\64 bit
- Microsoft Windows Server 2008, Tier 1, 32\64 bit
- Microsoft Windows Server 2008 R2, Tier 1, 64 bit
- Microsoft Windows Server 2012, Tier 1, 64 bit
- Microsoft Windows Server 2012 R2, Tier 1, 64 bit
- Red Hat Enterprise Linux 3, Tier 1, 32\64 bit
- Red Hat Enterprise Linux 4, Tier 1, 32\64 bit
- Red Hat Enterprise Linux 5, Tier 1, 32\64 bit
- Red Hat Enterprise Linux 6, Tier 1, 32\64 bit
- Red Hat Enterprise Linux 7, Tier 1, 32\64 bit
- SUSE Linux Enterprise Server 10, Tier 2, 32\64 bit
- SUSE Linux Enterprise Server 11, Tier 2, 32\64 bit
- SUSE Linux Enterprise Server 12, Tier 2, 32\64 bit

For PPC hosts:
- Red Hat Enterprise Linux 7, Tier 1, LE\BE
- Red Hat Enterprise Linux 6, Tier 1, BE
- SUSE Linux Enterprise Server 12, Teir 2, LE
- SUSE Linux Enterprise Server 11 SP4, Teir 2, BE